In the United States the Council organizes a major biennial Conference on economic and political developments in the U.S., Italy, and the transatlantic economic relationship.

High-level speakers have included Lamberto Dini, Stuart Eizenstat, Rudolph Giuliani, Richard Lugar, Mario Monti, Richard Parsons, Thomas Pickering, Ronald Spogli, Lawrence Summers, Giulio Tremonti, and Vincenzo Visco.